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Hydroxychloroquine has been used in combination with methotrexate, a disease-modifying antirheumatic drug (DMARD), in the treatment of rheumatoid arthritis to achieve better disease control and reduce the risk of joint damage. hcq This combination therapy targets different aspects of the immune response involved in the pathogenesis of rheumatoid arthritis, providing synergistic effects in suppressing inflammation and preserving joint function. Close monitoring of disease activity and adverse effects is essential when using combination therapy with hydroxychloroquine and methotrexate.