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The efficacy of ivermectin tablets against a wide range of parasites is attributed to its unique mode of action, which involves binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites, leading to paralysis and death. This mechanism selectively targets parasites while having minimal impact on mammalian cells, contributing to the drug's safety and tolerability. Additionally, ivermectin's long half-life allows for convenient once-a-year or once-every-six-month dosing regimens in certain indications, further enhancing its utility in mass drug administration programs.