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Despite its established safety profile, the misuse and overuse of ivermectin for humans can lead to adverse effects and the development of drug resistance. Inappropriate prescribing practices, self-medication, and suboptimal dosing regimens may contribute to treatment failures and undermine efforts to control parasitic infections. Therefore, it is essential for healthcare providers to adhere to established guidelines and promote rational drug use to maximize the benefits of stromectol while minimizing potential harms.